Abstract: The reaction-transportation model is established on basis of dissolution and precipitation reactions of calcite, dolomite and gypsum, the model consists of the reaction model which reveals the reaction processes of compositions as the time goes, the flow model which reveals the flow processes of water in the aquifer and the relation equation of chemical dynamic equation-flow equation. The reaction-transportation model is verified by the example in Jinan karst area. The reaction model is resolved with analysis method. The transportation model is resolved by the finite element method. The reaction rate constant and the hydraulics paramate are determined.