Abstract: 【Objective】 The helium abundance in shale gas reservoirs is relatively low, but the vast scale of reserves makes it a critical alternative source for future helium supply. The southeastern Sichuan region exhibits diverse structural styles, with varying preservation conditions across different structures. The distribution characteristics and enrichment patterns of helium in shale gas remain unclear. Clarifying the differential enrichment mechanisms of helium in shale gas is of great significance for the effective utilization of this resource. 【Method】 Taking typical shale gas reservoirs with different structural styles in the southeastern Sichuan Basin as the research focus, this study investigates the differential enrichment mechanisms of helium in shale gas across various structural patterns, aiming to identify potential favorable zones for helium exploration within shale gas plays. 【Results and Conclusions】 (1) Areas with poor structural preservation conditions and normal formation pressure - including residual synclines, fault-fold deformation zones, and shallow-buried fault anticlines - exhibit relatively high helium concentrations, averaging 524×10^-6, 606×10^-6, and 534×10^-6 respectively, which meet industrial helium extraction standards. In contrast, regions with better structural preservation conditions and overpressure environments - such as broad gentle anticlines, synclines, and deep-buried fault anticlines - show lower helium concentrations, averaging 335×10^-6, 381×10^-6, and 250×10^-6 respectively. (2) Helium in the Wufeng-Longmaxi shale gas reservoirs with different structural styles in southeastern Sichuan is predominantly crust-derived, exhibiting high helium-generation potential. However, no significant differences in helium-generation potential were observed among the various structural styles. Calculations based on uranium-thorium decay theory combined with helium-argon isotope analyses demonstrate that the helium in these shale gas reservoirs is primarily of endogenous origin, forming self-sourced and self-reservoired helium accumulations. (3) The differential helium enrichment observed in various structural styles within southeastern Sichuan primarily results from variations in preservation conditions and the associated differences in shale gas-helium system dissipation behavior, which collectively determine the degree of shale gas dilution. Additionally, the coupled effects of helium diffusion-enrichment in micro-nano pores and methane-induced physical clogging of migration pathways constitute another essential mechanism governing helium accumulation in these shale gas reservoirs. (4) Based on the helium enrichment mechanisms, low-pressure secondary zones outside the basin—such as the Qijiang, Wulong, Baima, and Pengshui blocks—are predicted to be potential favorable targets for helium exploration in shale gas, particularly in areas with lower shale gas quality. This insight may open new avenues for future helium exploration and development in shale gas systems.