Abstract: The uniform design is introduced into the sensitivity analysis of slope stability, which can greatly reduce the number of trials and make the test points uniformly distributed to obtain satisfactory results.Aimed at a typical cut slope of Hanglan highway, by uniform design, the sensibility of seven factors affecting slope stability was analyzed, on the same time, comparative analysis before and after excavation support was conducted by using analysis of finite element numerical simulation.The analysis confirmed the reliability of uniform design, obtained some preliminary rules for the road cutting slope.Factor sensitivity from the maximum to the minimum is internal friction angle, anchor length, unit weight, cohesion, anchor spacing, prestressing force, anchorage length, providing a firm basis for the comprehensive management of the highway slope.