Abstract: Because of constraints of manufacturing costs and process, timing crystal in seismograph with GPS clock has inevitably frequency error. So, in the process of data acquisition, with the increase in acquisition time, non-synchronous phenomenon occurs between acquisition stations. The paper describes the Akima piecewise polynomial interpolation resampling method and its application in time correction of seismograph GPS clock. Akima interpolation by theoretical data and actual data resampling test showed that Akima interpolation resampling method can be applied to travel time error correction of seismograph with GPS time, is a simple, efficient, good shape retention interpolation resampling method.