Abstract: In order to fully understand the reservoir pressure variation characteristics of coalbed methane wells in the southern block of Shizhuang and based on the analysis of reservoir geological parameters and the analysis of actual production data, the reservoir pressures of different types of production wells are analyzed. The specific analysis of the drainage control and reservoir sensitivity effects is also carried out based on the abnormal wells. The results showed that the reservoir lamination of coalbed methane wells in the southern block of Shizhuang can be divided into three types, namely type of rapid pressure drop, type of medium-term stability and type of slow pressure drop. Among them, most high gas production wells are of the type of rapid pressure drop, but too fast drainage and depressurization speed will cause reservoirs to be subjected to various sensitive effects, reduce reservoir permeability, and various factors lead to limited expansion of pressure drop funnels. Finally, the coalbed methane well is inhibited from reaching high yield.