Abstract: Time domain seismic data interpretation is relatively mature, and depth domain processing technology has been moved into the field of coal, but there are still many problems in the practical application of high density 3D seismic depth domain data interpretation in coal mining area. Through the exploration and application of coal seismic depth domain horizon calibration, depth domain fault interpretation and depth domain floor mapping, and referring to the process of time domain interpretation, the method of directly interpreting coal geological results in high density 3D seismic depth domain data is preliminarily established. Taking the application of 3D prestack depth migration seismic data in Qinan Coal Mine of Huaibei as an example, through the comparative analysis of seismic data in depth domain and time domain, fault interpretation, seismic attribute display of mining face and floor mapping, higher precision results have been achieved. The results of depth domain are conducive to the technical personnel of the front line to directly use the depth domain seismic data to guide the coal mine production.